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Serum Cystatin C Levels Could Predict Rapid Kidney Function Decline in A Community-Based Population
Wei-Ching Fang1, Hsing-Yu Chen2,3,4, Shao-Chi Chu5
1Department of Family Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Biomedicines
|November 11, 2022
Summary
Low serum cystatin C levels predict rapid kidney function decline in healthy individuals. This finding highlights cystatin C as a potential risk factor for kidney disease progression.
Area of Science:
- Nephrology
- Biomarker Research
- Preventive Medicine
Background:
- Chronic kidney disease (CKD) prevalence and severity are linked to various biomarkers.
- The association between biomarkers and rapid kidney function decline (RKFD) in healthy populations remains unestablished.
Purpose of the Study:
- To assess the predictive capability of biomarkers for identifying individuals at risk of developing RKFD.
- To investigate potential predictors of RKFD in a healthy cohort.
Main Methods:
- A community-based cohort of 2608 healthy individuals in Taiwan was monitored for renal function from 2014 to 2019.
- RKFD was defined as a 15% estimated glomerular filtration rate (eGFR) decrease within 4 years or a non-improving eGFR in the fifth year.
- Serum levels of adiponectin, leptin, tumor necrosis factor-alpha, and cystatin C were analyzed alongside clinical variables.
Main Results:
- The incidence of RKFD was 17.0%.
- Serum cystatin C demonstrated the strongest predictive performance for RKFD (AUC: 0.789).
- Lower cystatin C levels and eGFR were identified as independent predictors of RKFD.
Conclusions:
- Serum cystatin C levels can predict the likelihood of RKFD in healthy individuals.
- Low serum cystatin C should be recognized as a risk factor for RKFD.
- This study provides valuable insights for early detection and prevention strategies for kidney function decline.
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