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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Arrhythmic Burden in Cardiac Amyloidosis: What We Know and What We Do Not

Alessia Argirò1, Annamaria Del Franco1, Carlotta Mazzoni1

  • 1Tuscan Regional Amyloidosis Centre, Careggi University Hospital, 50134 Florence, Italy.

Biomedicines
|November 11, 2022
PubMed

Insights

Cardiac amyloidosis (CA) affects heart function and electrical activity. This review summarizes arrhythmias in CA and evaluates antiarrhythmic treatments, highlighting the need for more research.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Amyloidosis Research

Background:

  • Cardiac amyloidosis (CA) involves amyloid fibril deposition, impairing cardiac structures.
  • CA affects left ventricular function, atrial function, and the heart's conduction system.
  • Electrical system involvement in CA requires further investigation.

Purpose of the Study:

  • To review the arrhythmic burden associated with cardiac amyloidosis.
  • To summarize current evidence on antiarrhythmic treatments for CA patients.
  • To address the need for understanding molecular mechanisms and treatment efficacy.

Main Methods:

  • Literature review of studies on cardiac amyloidosis and arrhythmias.
  • Analysis of existing data on antiarrhythmic drug effectiveness in CA.
  • Synthesis of information on the electrical consequences of CA.

Main Results:

  • Cardiac amyloidosis significantly impacts cardiac electrical function.
  • Conflicting data exists regarding the efficacy of conventional antiarrhythmic strategies.
  • Further research is needed on molecular mechanisms and treatment outcomes.

Conclusions:

  • Arrhythmias are a significant clinical issue in cardiac amyloidosis.
  • Current antiarrhythmic treatments may have variable effectiveness in CA.
  • Understanding and managing the electrical aspects of CA is crucial for patient care.

Keywords:
arrhythmiasatrial fibrillationcardiac amyloidosispacemaker implantation

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