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Cellular-Based Therapies in Systemic Sclerosis: From Hematopoietic Stem Cell Transplant to Innovative Approaches

Elisabetta Xue1, Antonina Minniti2, Tobias Alexander3,4

  • 1Hematopoietic and Bone Marrow Transplant Unit, San Raffaele Hospital, 20132 Milan, Italy.

Cells
|November 11, 2022
PubMed

Insights

Systemic sclerosis (SSc) treatments are limited. Cellular therapies, including stem cell transplantation, offer new hope for restoring immune tolerance and promoting tissue regeneration in SSc patients.

Area of Science:

  • Immunology
  • Rheumatology
  • Cellular Therapy

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease marked by vasculopathy and fibrosis, leading to varied clinical presentations.
  • Current treatments for SSc offer limited efficacy and potential side effects, necessitating novel therapeutic strategies.
  • Cellular therapies aim to restore immune self-tolerance and promote tissue regeneration in SSc.

Purpose of the Study:

  • To review the current landscape of cellular therapies for Systemic sclerosis.
  • To explore pre-clinical and clinical applications of cellular therapies in SSc.
  • To discuss emerging advanced cellular therapies for SSc.

Main Methods:

  • Review of pre-clinical models and clinical studies on cellular therapies in SSc.
  • Analysis of autologous hematopoietic stem cell transplantation (HSCT) as a standard indication.
  • Exploration of mesenchymal stem cells, regulatory T cells, and CAR-T-cell therapies.

Main Results:

  • Autologous HSCT is a recommended standard indication for SSc by the European Society of Blood and Marrow Transplantation.
  • Cellular therapies show promise in addressing the autoimmune and fibrotic aspects of SSc.
  • Advanced cellular therapies are under investigation for SSc treatment.

Conclusions:

  • Cellular therapies represent a promising frontier for treating Systemic sclerosis.
  • Autologous HSCT is an established option, with ongoing research into novel cell-based approaches.
  • Future directions include exploring mesenchymal stem cells, regulatory T cells, and CAR-T-cell therapies for SSc.
Keywords:
adipose tissue graftingautoimmune diseasescell therapiesdigital ulcershematopoietic stem cell transplantationmesenchymal stem cellsskin fibrosissystemic sclerosis

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