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Aberrant B Cell Signaling in Autoimmune Diseases
Odilia B J Corneth1, Stefan F H Neys1, Rudi W Hendriks1
1Department of Pulmonary Medicine, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Cells
|November 11, 2022
Summary
Aberrant B cell receptor (BCR) signaling is key in autoimmune diseases. This review explores BCR and other signaling pathway disruptions, and therapeutic strategies targeting B cell signal transduction.
Area of Science:
- Immunology
- Molecular Biology
- Autoimmune Diseases
Background:
- Aberrant B cell signaling is central to autoimmune diseases.
- Genetic evidence and B cell studies support this role.
- Small-molecule inhibitors show therapeutic efficacy.
Purpose of the Study:
- Review key B cell receptor (BCR) signaling pathways.
- Discuss aberrant signaling in B cell selection and activation.
- Explore other implicated signaling pathways and therapeutic strategies.
Main Methods:
- Literature review of B cell signaling in autoimmunity.
- Analysis of BCR downstream pathways.
- Examination of co-inhibitory receptor phosphatases, BAFF, APRIL, and TLR synergy.
Main Results:
- Aberrant BCR signaling affects B cell repertoire selection and survival.
- Dysregulated phosphatases and increased BAFF/APRIL contribute to autoimmunity.
- Synergy between BCR and Toll-like receptors (TLRs) exacerbates autoimmunity.
Conclusions:
- B cell signaling pathways are critical targets for autoimmune disease therapies.
- Understanding these pathways offers insights into disease mechanisms.
- Targeting B cell signal transduction presents therapeutic opportunities.
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