The DNA Methylation in Neurological Diseases
Samareh Younesian1, Amir-Mohammad Yousefi1, Majid Momeny2
1Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran 1971653313, Iran.
Cells
|November 11, 2022
Summary
DNA methylation is crucial for brain function and neurological disease development. Altered DNA methylation patterns show strong links to disease progression and outcomes, offering potential clinical biomarkers.
Area of Science:
- Neuroscience
- Epigenetics
- Genomics
Background:
- DNA methylation is vital for human brain development and function, influencing processes like neural stem cell proliferation, synaptic plasticity, and memory.
- Despite the stability of DNA methylation, it has emerged as a key epigenetic modification with clinical relevance.
- Growing evidence links DNA methylation profiles to clinical outcomes in neurological disorders.
Purpose of the Study:
- To review the latest research on DNA methylation alterations in neurodegenerative, neurodevelopmental, and neuropsychiatric diseases.
- To highlight the association between DNA methylation changes and disease progression and outcomes.
Main Methods:
- Literature review of recent studies on DNA methylation in neurological diseases.
- Synthesis of evidence linking epigenetic alterations to disease development and progression.
Main Results:
- DNA methylation alterations are implicated in the pathogenesis of various neurological conditions.
- Specific DNA methylation profiles correlate with disease progression and patient outcomes in diseases like Alzheimer's and Parkinson's.
Conclusions:
- DNA methylation represents a significant area of study for understanding neurological diseases.
- DNA methylation profiles hold promise as valuable biomarkers for diagnosis, prognosis, and therapeutic strategies in neurology.
Keywords:
Alzheimer’s diseaseDNA methylationHuntington’s diseaseParkinson’s diseaseautismneurological disordersMore Related Videos
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