Related Experiment Video
Updated: Aug 22, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a
Shalini Rajagopal1,2,3, Akanksha Sharma4, Anita Simlot5
1Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Clappana 690525, India.
Abstract:
Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs) and variants associated with individual subpopulations of VK disease phenotypes, viz., myocardial infarction, renal failure and prostate cancer. We sought to ask whether or not any DEGs harbor pathogenic variants common in these conditions, attempt to bridge the gap in finding characteristic biomarkers and discuss the role of long noncoding RNAs (lncRNAs) in the biogenesis of VK deficiencies.
More Related Videos
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pleiotropy
Pedigree Analysis
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Vitamins
Incomplete Dominance

