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Association between Statin Use and Diabetes Risk in Patients with Transient Ischemic Attack.

Fu-Jun Chen1,2, Ming-Chien Yin3, Pei-Yun Chen1,4

  • 1Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan.

International Journal of Environmental Research and Public Health
|November 11, 2022
PubMed
Summary

Statin therapy, used to prevent recurrent transient ischemic attacks (TIAs), was found to lower the risk of developing new-onset diabetes mellitus (DM) in TIA patients. This study suggests statins may offer a protective effect against diabetes in this population.

Keywords:
cohort studydiabetes mellitusstatinstransient ischemic attack

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Epidemiology

Background:

  • Statin therapy is a cornerstone for reducing recurrent transient ischemic attack (TIA) risk.
  • Previous research indicates a potential association between statin use and increased incidence of diabetes mellitus (DM).
  • The specific impact of statin therapy on DM risk in patients with a history of TIA remains unclear.

Purpose of the Study:

  • To investigate the association between statin treatment and the risk of developing incident diabetes mellitus (DM) in patients diagnosed with transient ischemic attack (TIA).

Main Methods:

  • A retrospective cohort study design was employed using the Longitudinal Health Insurance Database 2000.
  • 8,342 patients newly diagnosed with TIA between 1997 and 2011 were analyzed.
  • Kaplan-Meier methods and Cox proportional risk models with time-dependent covariance were utilized for analysis.

Main Results:

  • Statin users (n=1,255) exhibited a significantly lower incidence of newly diagnosed DM compared to nonusers (n=7,087) over a 14-year follow-up (hazard ratio 0.545).
  • A dose-dependent relationship was observed, with higher cumulative defined daily doses (cDDDs) of statins correlating with progressively lower adjusted hazard ratios for DM.
  • Adjusted hazard ratios for DM decreased with increasing cDDDs: 0.689 (28-89 cDDDs), 0.594 (90-180 cDDDs), and 0.463 (>180 cDDDs).

Conclusions:

  • In patients with TIA, statin use is associated with a reduced risk of developing incident diabetes mellitus compared to non-statin users.
  • The findings suggest that statins may have a protective effect against new-onset diabetes in the TIA population.
  • Further research may explore the mechanisms underlying this protective association.