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Intraoperative Tumor Detection Using Pafolacianine.

Mihaela Elisabeta Dindere1,2, Antoanela Tanca1,2, Mihaela Rusu3

  • 1Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.

International Journal of Molecular Sciences
|November 11, 2022
PubMed
Summary

Intraoperative near-infrared imaging with pafolacianine helps surgeons detect and remove difficult-to-see cancer during surgery. This FDA-approved fluorescent imaging agent improves tumor resection, potentially reducing cancer recurrence and enhancing patient outcomes.

Keywords:
fluorescent imagingfolate receptorintraoperativenear-infrared spectrumpafolacianinetumor detection

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Area of Science:

  • Surgical Oncology
  • Medical Imaging
  • Cancer Therapeutics

Background:

  • Surgery is crucial for cancer removal, but incomplete resection leads to relapse.
  • Current methods rely on visual and tactile feedback, often missing malignant tissue.
  • Pafolacianine offers a new approach for intraoperative cancer detection.

Purpose of the Study:

  • To review the applications of FDA-approved pafolacianine for intraoperative malignant tissue detection.
  • To highlight pafolacianine's role in improving surgical oncology outcomes.
  • To discuss the potential of fluorescent imaging in enhancing cancer surgery.

Main Methods:

  • Review of studies on pafolacianine's use in various malignancies.
  • Focus on intraoperative near-infrared imaging with pafolacianine.
  • Analysis of safety and efficacy data for pafolacianine.

Main Results:

  • Pafolacianine is FDA-approved for ovarian cancer, aiding in malignant lesion identification and total tumor resection.
  • Demonstrated positive effects in detecting various other cancers.
  • Proven safety and efficacy in clinical applications.

Conclusions:

  • Pafolacianine enables visualization of difficult-to-detect cancer lesions during surgery.
  • Enhanced detection and removal of tumors can significantly decrease relapse rates.
  • This technology promises improved patient outcomes, quality of life, and reduced healthcare costs.