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Decellularized Extracellular Matrix-Based Bioinks for Tendon Regeneration in Three-Dimensional Bioprinting
Fouad Al-Hakim Khalak1,2,3, Fátima García-Villén1,2,3, Sandra Ruiz-Alonso1,2,3
1NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.
International Journal of Molecular Sciences
|November 11, 2022
Summary
Combining 3D bioprinting with decellularized extracellular matrix (dECM) bioinks shows promise for tendon regeneration. This approach offers a potential solution to limitations of current graft treatments for damaged tendons.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Rising demand for improved tendon regeneration treatments.
- Limitations of current graft-based therapies, including insufficient support and complications.
- Emerging interest in decellularized extracellular matrix (dECM) and 3D bioprinting for tissue repair.
Purpose of the Study:
- To investigate the potential of dECM bioinks combined with 3D bioprinting for tendon regeneration.
- To address challenges associated with dECM bioink properties and printing parameters.
Main Methods:
- Obtaining tendon dECM using various decellularization treatments (chemical, biological, physical).
- Formulating dECM into bioinks for 3D bioprinting applications.
- Optimizing printing parameters (e.g., speed, temperature) for dECM bioinks.
Main Results:
- Demonstrated that dECM bioinks can mimic native tendon composition and structure.
- Identified challenges including poor structural integrity and slow gelation of dECM bioinks.
- Highlighted the necessity of optimizing printing parameters for successful dECM bioink application.
Conclusions:
- 3D bioprinting utilizing dECM bioinks presents a promising strategy for tendon regeneration.
- This approach holds potential for future clinical applications in treating tendon injuries.
- Further research is needed to overcome current limitations and standardize protocols.
