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Arrhythmias and Conduction Disturbances in Patients with Systemic Sclerosis-A Systematic Literature Review

Cristina Andreea Vrancianu1,2, Ana Maria Gheorghiu1,2, Dragos Emanuel Popa3

  • 1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

International Journal of Molecular Sciences
|November 11, 2022
PubMed

Insights

Arrhythmias are common in Systemic sclerosis (SSc), often linked to heart fibrosis. Biomarkers like NT-pro BNP and turbulence slope can help predict these cardiac events in SSc patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Systemic sclerosis (SSc) is an autoimmune condition causing fibrosis and microvascular issues, frequently impacting the heart.
  • Arrhythmias contribute significantly to mortality in SSc patients, primarily due to myocardial fibrosis-induced electrical inhomogeneity.

Approach:

  • A systematic literature review was conducted across major databases (PubMed, Embase, Web of Science, Scopus) up to April 21, 2022.
  • Included full-text English articles focusing on arrhythmias in SSc patients.

Key Points:

  • Premature supraventricular and ventricular contractions were the most common arrhythmias.
  • Right bundle branch block (RBBB) was the most frequent conduction disturbance.
  • Elevated NT-pro BNP levels correlated with various arrhythmias and RBBB; a lower turbulence slope predicted ventricular arrhythmias.

Conclusions:

  • Dysrhythmias are prevalent in Systemic sclerosis cohorts.
  • Paraclinical and laboratory markers, such as NT-pro BNP and turbulence slope, are valuable for early detection of cardiac complications in SSc.

Keywords:
arrhythmiasconduction disturbancessystemic sclerosis

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