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Updated: Aug 22, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
Solutions to a Radical Problem: Overview of Current and Future Treatment Strategies in Leber's Hereditary Opic
Samuel J Spiegel1, Alfredo A Sadun2
1Gavin Herbert Eye Institute, University of California, Irvine, CA 92617, USA.
Abstract:
Leber's Hereditary Optic Neuropathy (LHON) is the most common primary mitochondrial DNA disorder. It is characterized by bilateral severe central subacute vision loss due to specific loss of Retinal Ganglion Cells and their axons. Historically, treatment options have been quite limited, but ongoing clinical trials show promise, with significant advances being made in the testing of free radical scavengers and gene therapy. In this review, we summarize management strategies and rational of treatment based on current insights from molecular research. This includes preventative recommendations for unaffected genetic carriers, current medical and supportive treatments for those affected, and emerging evidence for future potential therapeutics.
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