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Cyclodextrin-Based Polymeric Materials Bound to Corona Protein for Theranostic Applications
Donya Esmaeilpour1,2, Jens Albert Broscheit3, Sergey Shityakov4
1Department of Chemistry, University of Isfahan, Isfahan 8174673441, Iran.
International Journal of Molecular Sciences
|November 11, 2022
Summary
Cyclodextrins (cyclic oligosaccharides) offer advanced theranostic applications in personalized medicine by enhancing drug delivery. Their unique structures enable complexation with biomolecules and formation of protein-coated polymers for improved biodistribution and therapeutic strategies.
Area of Science:
- Biomedical Science
- Materials Science
- Nanotechnology
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with amphiphilic properties, featuring hydrophobic cavities and hydrophilic exteriors.
- CDs are versatile excipients used to improve drug solubility, stability, and bioavailability, and for controlled molecular delivery.
- Their unique host-guest complexation ability allows interaction with various biomolecules, including peptides and proteins.
Purpose of the Study:
- To review the biomedical applications of cyclodextrin-based polymers (CDbPs) for theranostic purposes.
- To highlight the role of protein corona in modulating the properties of CDbPs for improved biodistribution and therapeutic efficacy.
- To explore the potential of CD-based host-guest interactions in advancing personalized medicine.
Main Methods:
- Review of existing literature on cyclodextrin-based polymers and their theranostic applications.
- Analysis of host-guest interactions between cyclodextrins and biomolecules.
- Investigation of protein corona formation on cyclodextrin-based nanoparticles.
- Evaluation of pharmacokinetic and pharmacodynamic properties of CDbPs.
Main Results:
- CD-based polymers (CDbPs) demonstrate significant potential for drug delivery and theranostics.
- Protein corona formation on CDbPs can enhance nanoparticle circulation time and biodistribution.
- Host-guest complexation is a key mechanism for targeted delivery and therapeutic enhancement.
- CDbPs offer tunable properties for optimized pharmacokinetic and pharmacodynamic profiles.
Conclusions:
- Cyclodextrin-based polymers represent a promising platform for developing advanced theranostic agents in personalized medicine.
- Understanding and engineering protein corona interactions are crucial for maximizing the therapeutic benefits of CDbPs.
- Host-guest chemistry provides a powerful tool for designing novel drug delivery systems with improved efficacy and safety.
