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Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis
El Chérif Ibrahim1,2, Victor Gorgievski3,4, Pilar Ortiz-Teba5
1Aix-Marseille Univ, CNRS, INT, Inst Neurosci Timone, 13005 Marseille, France.
International Journal of Molecular Sciences
|November 11, 2022
Summary
Antidepressants are crucial for major depressive episodes, but response is inconsistent. This review analyzes animal models to find new biomarkers for better antidepressant treatment strategies.
Area of Science:
- Neuroscience
- Pharmacology
- Genomics
Background:
- Antidepressants (ADs) are first-line treatments for major depressive episodes (MDEs), but efficacy varies, with over 60% of patients not responding to initial treatment.
- Current prescription strategies are trial-and-error, lacking biomarkers for personalized medicine, unlike in oncology.
- Understanding the molecular mechanisms of AD response is critical for improving treatment outcomes.
Conclusions:
- The study identifies potential transcriptional biomarkers for antidepressant response by analyzing animal models.
- Findings suggest the importance of synaptic plasticity pathways in antidepressant mechanisms.
- Emphasizes the need for systematic, sex-inclusive, and multi-tissue studies across different antidepressant classes.
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