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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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Genetic and Functional Effects of Adiponectin in Type 2 Diabetes Mellitus Development
Yu-Hui Tang1, Yeh-Han Wang2, Chin-Chang Chen3
1Department of Medical Genetics, China Medical University Hospital, Taichung 40447, Taiwan.
International Journal of Molecular Sciences
|November 11, 2022
Summary
Adiponectin levels are lower in type 2 diabetes mellitus (T2DM) patients and T2DM mice. Specific adiponectin gene variations increase T2DM risk, suggesting adiponectin
Area of Science:
- Endocrinology and Metabolism
- Genetics and Genomics
Background:
- Type 2 diabetes mellitus (T2DM) is a prevalent chronic metabolic disorder.
- Adiponectin is a key hormone involved in glucose and lipid metabolism.
- C57BLKsJ-db/db mice serve as a relevant model for studying T2DM.
Purpose of the Study:
- To investigate the role of adiponectin in T2DM progression using mouse models.
- To examine the association between adiponectin gene single nucleotide polymorphisms (SNPs) and T2DM in a Taiwanese population.
- To analyze serum adiponectin concentrations in T2DM patients and healthy controls.
Main Methods:
- Western blotting and immunohistochemistry (IHC) to assess liver adiponectin protein expression in T2DM mice.
- Genotyping and allelic frequency analysis of adiponectin gene SNPs (rs1063538, rs2241766) in a Taiwanese cohort.
- Enzyme-linked immunosorbent assay (ELISA) to quantify serum adiponectin levels.
Main Results:
- Adiponectin expression was reduced in the liver tissues of T2DM mice across different disease durations.
- The T allele of the adiponectin gene rs2241766 was more frequent in T2DM patients than controls.
- Carrying the G allele of rs2241766 was associated with an increased risk of developing T2DM.
- Serum adiponectin concentrations were significantly lower in T2DM patients compared to healthy individuals.
Conclusions:
- Adiponectin plays a role in T2DM pathogenesis and progression.
- Adiponectin is identified as a susceptibility gene for T2DM.
- Genetic variations in the adiponectin gene are linked to T2DM risk.
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