Related Experiment Video
Updated: Aug 22, 2025
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory
Nikita Zernov1, Alexander V Veselovsky2, Vladimir V Poroikov2
1Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, 195251 St. Petersburg, Russia.
A new drug candidate, C20, targeting the TRPC6 channel, shows promise for Alzheimer's disease. It protects synapses, improves brain function in mice, and may treat cognitive decline by addressing synaptic deficiency.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline.
- Targeting synaptic protection offers a potential therapeutic strategy for AD.
- The TRPC6 channel is crucial for excitatory synapse formation and cognitive function.
Purpose of the Study:
- To evaluate a novel selective TRPC6 agonist (C20) for its therapeutic potential in Alzheimer's disease.
- To investigate the compound's efficacy in preclinical models of AD.
Main Methods:
- In silico, in vitro, ex vivo, pharmacokinetic, and in vivo studies were conducted.
- Assessed TRPC6 binding, protection against amyloid toxicity, synaptic plasticity recovery, blood-brain barrier penetration, and cognitive function in 5xFAD mice.
Main Results:
- The compound C20 selectively binds to human TRPC6.
- It protects hippocampal synapses from amyloid toxicity in vitro.
- C20 recovers synaptic plasticity in 5xFAD brain slices and cognitive deficits in 5xFAD mice.
- The compound demonstrates blood-brain barrier penetration.
Conclusions:
- The novel TRPC6 agonist C20 exhibits significant therapeutic potential for Alzheimer's disease.
- C20 effectively targets synaptic deficiency in AD models.
- This compound may represent a novel drug for treating synaptic dysfunction in Alzheimer's disease.
More Related Videos
07:43Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
Published on: May 12, 2015
06:22A Pilot Study on the Repetitive Transcranial Magnetic Stimulation of Aβ and Tau Levels in Rhesus Monkey Cerebrospinal Fluid
Published on: September 3, 2021