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An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children
Angela Klain1, Giulio Dinardo1, Alessandra Salvatori1
1Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Insights
Non-allergic asthma is uncommon in children but triggered by various factors. Identifying causes is key for effective treatment, especially in those unresponsive to standard therapies.
Area of Science:
- Pediatric Pulmonology
- Immunology
Background:
- Non-allergic asthma, distinct from allergic asthma, is less common in children.
- Triggers include environmental factors like cold air, infections, smoke, and pollution, rather than allergens.
- Limited research exists on pediatric non-allergic asthma, highlighting a knowledge gap.
Purpose of the Study:
- To review the current understanding of non-allergic asthma in pediatric patients.
- To explore the etiopathogenesis of non-IgE-mediated asthma in children.
- To summarize recent advancements in treating non-allergic asthma in this age group.
Main Methods:
- Literature review of studies on non-allergic asthma in children.
- Analysis of research on non-IgE-mediated asthma triggers and mechanisms.
- Synthesis of current treatment strategies for pediatric non-allergic asthma.
Main Results:
- Non-allergic asthma in children is characterized by diverse triggers beyond allergens.
- Understanding non-IgE-mediated pathways is crucial for diagnosis and management.
- Few studies specifically address pediatric non-allergic asthma.
Conclusions:
- Early identification of non-allergic asthma triggers in children is vital for management.
- Further research is needed to elucidate the etiopathogenesis and optimize treatments for pediatric non-allergic asthma.
- This review consolidates current knowledge on non-allergic asthma in pediatric populations.
Abstract:
The prevalence of non-allergic asthma in childhood is low, peaking in late adulthood. It is triggered by factors other than allergens, like cold and dry air, respiratory infections, hormonal changes, smoke and air pollution. In the literature, there are few studies that describe non-allergic asthma in pediatric age. Even though it is a less common disorder in kids, it is crucial to identify the causes in order to keep asthma under control, particularly in patients not responding to conventional treatments. In this review, we discuss non-IgE-mediated forms of asthma, collecting the latest research on etiopathogenesis and treatment.
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