Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

300
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
300
Long-term Potentiation01:35

Long-term Potentiation

55.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.6K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.4K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.4K
Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

1.7K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasound-Guided 5% Dextrose Hydrodissection Procedures for Persistent and Recurrent Post-Surgical Carpal Tunnel Syndrome: A Prospective Single-Center Cohort Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Carbapenem-Resistant <i>Klebsiella pneumoniae</i>: Carbapenemase Production, Antibiotic Resistance and Treatment Options, in an Infectious Diseases Hospital from Romania.

Antibiotics (Basel, Switzerland)·2026
Same author

Cardiopulmonary transit time measured on dynamic rubidium cardiac PET/CT is a predictor for pulmonary hypertension.

EJNMMI research·2026
Same author

Insight into Haploinsufficiency of the ERBB4 Gene: Expanding the Spectrum of Associated Phenotypes.

Journal of autism and developmental disorders·2026
Same author

Hybrid Cardiac Rehabilitation as an Optimal Strategy for Post-MI Recovery: A 14-Week Prospective Study on Clinical and Functional Outcomes.

Healthcare (Basel, Switzerland)·2026
Same author

Biomechanical Factors and Prevention Strategies for Sports-Related Muscle Injuries: A Narrative Review.

Bioengineering (Basel, Switzerland)·2026

Related Experiment Video

Updated: Aug 22, 2025

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

2.3K

Lithium Biological Action Mechanisms after Ischemic Stroke.

Constantin Munteanu1,2, Mariana Rotariu1, Marius Turnea1

  • 1Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa" Iași, 700454 Iași, Romania.

Life (Basel, Switzerland)
|November 11, 2022
PubMed
Summary

Lithium, despite its simple structure, has complex biological effects, including neuroprotection and mood stabilization. Further research is needed to fully understand its mechanisms of action, particularly after ischemic stroke.

Keywords:
ischemic strokelithiumreview

More Related Videos

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.8K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

20.3K

Related Experiment Videos

Last Updated: Aug 22, 2025

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

2.3K
The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Published on: July 25, 2011

19.8K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

20.3K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Lithium's simple structure belies complex, multifaceted biological effects.
  • Historically used for gout and mania, its therapeutic mechanisms remain incompletely understood.
  • Lithium influences neurotransmission, ion transport, gene expression, and circadian rhythms.

Purpose of the Study:

  • To explore the diverse biological actions of lithium.
  • To review lithium's historical therapeutic applications and evolving understanding.
  • To investigate lithium's potential neuroprotective effects, especially post-ischemic stroke.

Main Methods:

  • Literature review of historical and recent studies on lithium's effects.
  • Analysis of biochemical and cellular mechanisms of lithium action.
  • Examination of clinical evidence for lithium's efficacy in mood disorders and neuroprotection.

Main Results:

  • Lithium demonstrates significant effects on multiple cellular and molecular processes.
  • Established efficacy in preventing manic and depressive recurrences in bipolar disorder.
  • Emerging evidence suggests neuroprotective benefits after ischemic stroke, with both short-term and long-term effects.

Conclusions:

  • Lithium's multifactorial actions require further elucidation.
  • Its role in neuroprotection warrants continued investigation, particularly regarding mechanisms post-stroke.
  • Understanding lithium's complex pharmacology is crucial for optimizing therapeutic applications.