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Published on: February 13, 2016
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Controlled Drug Release Using Chitosan-Alginate-Gentamicin Multi-Component Beads.
Kyung Hee Park1, Yeon Woo Choi2, Heejoo Ryu1
1Department of Dental Materials and Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Materials (Basel, Switzerland)
|November 11, 2022
Summary
Researchers developed chitosan-alginate beads for controlled antibiotic delivery. Citric acid crosslinking enabled sustained release of gentamicin, showing potential for bone restoration applications.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Pharmaceutical Technology
Background:
- Bone defects and infections often require localized antibiotic delivery to enhance efficacy and minimize systemic side effects.
- Developing effective drug delivery systems for antibiotics like gentamicin (GM) is crucial for bone restoration and infection control.
- Chitosan and alginate are biocompatible polymers with potential for creating versatile drug delivery matrices.
Purpose of the Study:
- To develop and characterize multi-component beads for controlled and sustained delivery of gentamicin (GM).
- To investigate the influence of chitosan concentration and citric acid crosslinking on GM release kinetics.
- To evaluate the suitability of these beads for bone restoration applications requiring antibiotic release.
Main Methods:
- Preparation of single and multi-component beads via gelation using chitosan, calcium chloride, alginate, and citric acid.
- Optimization of bead composition (sodium alginate, chitosan, citric acid concentrations) for desired release profiles.
- Characterization of beads using FTIR, TG-DTG, swelling studies, and SEM.
- In vitro release studies of gentamicin in phosphate buffer solution.
- Assessment of antimicrobial activity of GM-loaded beads.
Main Results:
- Optimized beads were formulated using 5% or 2% sodium alginate, 3% chitosan, and 0.1 mol/L citric acid.
- Characterization confirmed the structural integrity and properties of the developed beads.
- All gentamicin-loaded beads exhibited significant antimicrobial activity.
- Chitosan concentration and citric acid crosslinking effectively controlled the rate and kinetics of GM release.
- Crosslinked beads achieved approximately 80% drug release within 24 hours, demonstrating sustained-release capability.
Conclusions:
- Chitosan-alginate beads offer a promising platform for antibiotic delivery.
- Citric acid crosslinking is an effective strategy to achieve sustained gentamicin release from these beads.
- The developed beads show potential for use in bone restoration, providing localized and controlled antibiotic therapy.
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