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Is There a Universal Endurance Microbiota?

Hope Olbricht¹, Kaitlyn Twadell¹, Brody Sandel¹

¹Department of Biology, Santa Clara University, Santa Clara, CA 95053, USA.

|November 11, 2022

Summary

This summary is machine-generated.

Researchers reanalyzed gut microbiota data from endurance athletes, finding no consistent bacterial differences across studies. Larger sample sizes are needed to identify a specific "endurance microbiota" and understand its impact on athletic performance.

Keywords:

16S gene sequences Romboutsia Veillonella barcode network workflow

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Area of Science:

Microbiology
Exercise Physiology
Bioinformatics

Background:

The gut microbiota influences host physiology, and its role in endurance athletes' performance is of significant interest.
Previous studies suggest an
Endurance microbiota
but identified bacterial taxa vary considerably between studies.

Purpose of the Study:

To identify consistent microbial taxa associated with endurance athletes by reanalyzing existing 16S rRNA gene sequence datasets.
To investigate variations in gut microbiota composition, diversity, and correlations within endurance athletes compared to controls.

Main Methods:

A standardized bioinformatics workflow was applied to four independent 16S rRNA gene sequence datasets.
Analysis included diversity metrics, relative abundance of bacterial taxa, correlation analyses, and association network construction.
Statistical significance and consistency across datasets were evaluated.

Main Results:

No significant differences in alpha diversity were observed across all datasets.
Only one dataset showed a significant overall difference in bacterial community abundance.
No bacterial genera exhibited consistently different relative abundance across all four datasets; only Veillonella and Romboutsia showed differences in two datasets.
No consistent changes in correlated bacterial abundances were found across datasets.
Power analysis indicated a need for substantially larger sample sizes to detect modest differences in relative abundance.

Conclusions:

The existence of a universally defined
endurance microbiota
remains elusive due to high inter-study variability.
Comparing microbiota studies presents significant challenges, necessitating standardized methods and larger sample sizes.
Further research with larger cohorts is required to elucidate the specific microbial signatures associated with endurance performance.