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Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

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A Portable, Negative-Pressure Actuated, Dynamically Tunable Microfluidic Droplet Generator.

Martin Trossbach1, Marta de Lucas Sanz1, Brinton Seashore-Ludlow2

  • 1KTH Royal Institute of Technology & Science for Life Laboratory, 17165 Solna, Sweden.

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Summary
This summary is machine-generated.

This study presents an affordable, user-friendly droplet microfluidics setup for non-experts. The minimal system, built from commercial parts, enables high-throughput droplet production and cell spheroid generation, promoting wider adoption in life sciences.

Keywords:
droplet microfluidicsmicrotissuesplug &amp; playportable microfluidicsspheroids

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Cell Biology

Background:

  • Droplet microfluidics offers high-throughput microscale manipulation but faces adoption barriers due to complex, costly setups.
  • Custom devices and specialized equipment hinder use in non-expert laboratories, limiting broader applications in life sciences.

Purpose of the Study:

  • To develop an accessible, low-cost droplet microfluidics system for broader laboratory use.
  • To demonstrate a minimal, easy-to-operate setup for droplet production and cell spheroid generation.

Main Methods:

  • Construction of a minimal droplet microfluidics setup using inexpensive, commercially available components.
  • Characterization of droplet production across a range of volumes (3–21 nL) within a single device.
  • Demonstration of dynamic droplet composition tuning and droplet-templated primary cell spheroid formation.

Main Results:

  • Successful production of monodisperse droplets from 3 to 21 nL using the minimal setup.
  • Demonstrated dynamic control over droplet contents and successful generation of cell spheroids.
  • The system's mobility and simplicity allow for operation within a biosafety cabinet.

Conclusions:

  • The developed minimal droplet microfluidics setup is user-friendly, cost-effective, and versatile.
  • This accessible technology has the potential to significantly increase the adoption of droplet microfluidics in diverse research settings.
  • The system facilitates applications ranging from precise droplet manipulation to the formation of cell spheroids.