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Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
Talha Bin Emran1,2, Fahadul Islam2, Saikat Mitra3
1Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.
Molecules (Basel, Switzerland)
|November 11, 2022
Summary
Modified pectin (MP), a soluble dietary fiber from fruits, shows anti-cancer properties. Research suggests modified citrus pectin (MCP) may inhibit tumor development and proliferation, warranting further clinical investigation.
Area of Science:
- Plant biochemistry
- Dietary fiber research
- Cancer chemoprevention
Background:
- Pectin is an acidic heteropolysaccharide in plant cell walls, widely used in food as a gelling and stabilizing agent.
- Dietary carbohydrates, including pectin, play a role in preventing chronic diseases like diabetes and heart disease.
- Modified pectin (MP), particularly modified citrus pectin (MCP), is investigated for its potential anti-cancer effects beyond its role as a soluble fiber.
Purpose of the Study:
- To review the modifications of pectin for developing MP.
- To explore the benefits of MP for cancer prevention, bioavailability, and clinical applications.
- To summarize toxicity studies related to modified pectin.
Main Methods:
- Literature review focusing on modifications of pectin.
- Analysis of cellular, animal, and human clinical trial data on MP efficacy.
- Examination of studies on pectin bioavailability and toxicity.
Main Results:
- Pectin, especially MP and MCP, demonstrates anti-cancer characteristics.
- Evidence suggests inhibition of tumor development and proliferation across various cancer types.
- Data from cellular, animal, and human studies support the potential benefits of MP.
Conclusions:
- Pectin exhibits anti-cancer properties that can inhibit tumor growth and spread.
- Modified pectin, particularly MCP, shows promise for cancer prevention and potentially therapy.
- Further clinical and basic research is necessary to confirm the therapeutic role of specific pectin molecules.
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