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Solvents01:12

Solvents

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A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
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Solvating Effects02:12

Solvating Effects

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An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...
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Physical Properties of Alcohols and Phenols02:32

Physical Properties of Alcohols and Phenols

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Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of...
14.8K
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

172
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
172
Physical Properties of Ethers02:17

Physical Properties of Ethers

7.3K
Overview
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...
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Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Updated: Aug 22, 2025

Extraction and Analysis of Taiwanese Green Propolis
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Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

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Propolis Efficacy: The Quest for Eco-Friendly Solvents.

Ana Sofia Freitas1,2,3, Ana Cunha2,3, Pier Parpot4,5

  • 1CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Minho, 4710-057 Braga, Portugal.

Molecules (Basel, Switzerland)
|November 11, 2022
PubMed
Summary

This study explored propolis extraction using novel apiary-derived solvents like honey brandy and mead. These eco-friendly solutions yielded potent antioxidant and antimicrobial propolis extracts.

Keywords:
antibacterial activityantioxidant potentialphenolic compoundspropolispropolis extractionpropolis extraction solvents

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Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
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Area of Science:

  • Natural Products Chemistry
  • Bee Product Research
  • Antimicrobial and Antioxidant Studies

Background:

  • Propolis, a bee-derived resin, possesses complex chemistry and significant bioactivities.
  • Traditional propolis extraction often relies on conventional solvents.
  • Exploring alternative, eco-friendly solvents is crucial for sustainable natural product utilization.

Purpose of the Study:

  • To investigate the efficacy of less conventional solvents, including apiary products, for propolis extraction.
  • To evaluate the influence of different solvents on the chemical composition and bioactivities of propolis extracts.
  • To assess the antioxidant and antimicrobial potential of propolis extracts obtained using novel solvents.

Main Methods:

  • Propolis extraction via maceration using six solvents: ethanol, ethanol/water, honey brandy, mead, propylene glycol, and water.
  • Antioxidant activity assessment using the DPPH free-radical-scavenging assay.
  • Antimicrobial activity evaluation via the agar dilution method.
  • Chemical composition analysis including total ortho-diphenols, phenolics, flavonoids, and LC-MS.

Main Results:

  • Honey brandy effectively extracted compounds inhibiting *Staphylococcus aureus* and *Propionibacterium acnes*.
  • Mead extracts demonstrated high antioxidant capacity (EC50 = 1.63 ± 0.27 µg/mL) and activity against resistant bacteria like MRSA and *E. coli*.
  • This study is the first to investigate honey brandy and mead as propolis extraction solvents.

Conclusions:

  • Apiary-derived solvents like honey brandy and mead are effective for extracting bioactive compounds from propolis.
  • These novel extraction methods offer eco-friendly alternatives, promoting diversification of apiary products.
  • The findings support the exploration of new applications for propolis using sustainable solutions.