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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Synthesis and Properties of Degradable Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) [P(3HB-<i>co</i>-3HV)] Derived from Waste Fish Oil.

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Topography hierarchy of biocompatible polyhydroxyalkanoate film.

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Benchmarking Unsupervised Clustering Algorithms for Atomic Force Microscopy Data on Polyhydroxyalkanoate Films.

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Biosynthesis of Polyhydroxyalkanoates in <i>Cupriavidus necator</i> B-10646 on Saturated Fatty Acids.

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Correction: Volova et al. Laser Processing of Polymer Films Fabricated from PHAs Differing in Their Monomer Composition. <i>Polymers</i> 2021, <i>13</i>, 1553.

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Properties of Degradable Polyhydroxyalkanoates Synthesized from New Waste Fish Oils (WFOs).

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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Resorbable Nanomatrices from Microbial Polyhydroxyalkanoates: Design Strategy and Characterization.

Ekaterina I Shishatskaya1,2, Alexey E Dudaev1,3, Tatiana G Volova3,4

  • 1Department of Medical Biology, School of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodnyi Av., 660041 Krasnoyarsk, Russia.

Nanomaterials (Basel, Switzerland)
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

Biodegradable polyhydroxyalkanoates (PHAs) films and nanomembranes show high biocompatibility for cell growth. Non-oriented nanomembranes from P(3HB-co-4HB) copolymers significantly enhance skin wound healing, demonstrating their potential as advanced wound dressings.

Keywords:
biodegradable polyhydroxyalkanoates (PHAs)cell culturescopolymersfilmshealing of skin woundsnanomembranespropertieswound coverings

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Polyhydroxyalkanoates (PHAs) are biodegradable polyesters with potential biomedical applications.
  • Developing advanced wound dressings requires materials with excellent biocompatibility and regenerative properties.

Purpose of the Study:

  • To investigate the surface, mechanical, and biological properties of PHA-based films and nanomembranes.
  • To evaluate the efficacy of these materials as experimental wound dressings for skin lesions.

Main Methods:

  • Fabrication of PHA films and nanomembranes using solvent casting and electrospinning.
  • Characterization using SEM, AFM, contact angle measurements, and mechanical testing.
  • In vitro cell culture studies with mouse fibroblasts and human embryonic cells.
  • In vivo testing on laboratory animals with induced skin defects.

Main Results:

  • P(3HB-co-4HB) copolymers exhibited high biocompatibility, supporting cell adhesion, proliferation, and viability for up to 7 days.
  • PHA films and nanomembranes, particularly those coated with collagen, showed positive results as experimental wound dressings.
  • Non-oriented nanomembranes produced by electrospinning demonstrated the most active regeneration of skin defects in animal models.

Conclusions:

  • Biodegradable P(3HB-co-4HB) copolymers are highly biocompatible and suitable for biomedical applications.
  • Non-oriented electrospun nanomembranes from P(3HB-co-4HB) are effective in promoting skin wound healing.
  • These advanced nanomembranes hold significant promise as next-generation wound dressing materials.