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Vitamin Status in Children with Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutation

Paulina Wysocka-Wojakiewicz1, Halina Woś2, Tomasz Wielkoszyński3

  • 1Department of Pediatrics, Faculty of Medical Sciences, Medical University of Silesia, 40-752 Katowice, Poland.

Nutrients
|November 11, 2022
PubMed

Insights

Children with cystic fibrosis screen positive, inconclusive diagnosis (CFSPID) had higher vitamin D and E levels than those with cystic fibrosis (CF). However, neither group fully met dietary vitamin recommendations.

Area of Science:

  • Pediatric Nutrition
  • Clinical Biochemistry
  • Genetic Disorders

Background:

  • Vitamin metabolism is not well understood in children with cystic fibrosis screen positive, inconclusive diagnosis (CFSPID).
  • Assessing vitamin A, D, E, and C status is crucial for this population.

Purpose of the Study:

  • To determine the blood concentrations of vitamins A, D, E, and C in children with CFSPID.
  • To compare vitamin status and intake between children with CFSPID, cystic fibrosis (CF), and healthy children (HC).

Main Methods:

  • Study included 89 children: 28 CFSPID, 31 CF, and 30 HC.
  • Blood vitamin levels (A, D, E, C) and dietary intake were analyzed using a three-day food diary.

Main Results:

  • CFSPID children showed significantly higher serum vitamin D and E compared to CF children.
  • No vitamin A or E deficiencies were observed in CFSPID patients.
  • CF patients had higher dietary intake of vitamins D and E, but many CF patients had inadequate calorie, vitamin E, and vitamin A intake.

Conclusions:

  • Children with CF and CFSPID do not meet all dietary vitamin recommendations.
  • Vitamin deficiency was identified exclusively in children with CF, not in the CFSPID group.
Abstract

Keywords:
CFSPIDcystic fibrosisinconclusive diagnosisvitamin A, D, E, and C

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