Related Experiment Video

Updated: Aug 22, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K

Aspergillus-SARS-CoV-2 Coinfection: What Is Known?

Carlos Alberto Castro-Fuentes1, María Del Rocío Reyes-Montes1, María Guadalupe Frías-De-León2

  • 1Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Ciudad Universitaria, Coyoacán, Mexico City 04510, Mexico.

Pathogens (Basel, Switzerland)
|November 11, 2022
PubMed

Insights

COVID-19-associated pulmonary aspergillosis (CAPA) is common and linked to longer hospital stays. This review identifies fungal, environmental, and host factors, plus SARS-CoV-2

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • COVID-19-associated pulmonary aspergillosis (CAPA) presents a significant clinical challenge with high incidence and prolonged hospitalizations.
  • Numerous factors contribute to CAPA development, including fungal characteristics, hospital environment, host comorbidities, and immunosuppressive treatments.
  • SARS-CoV-2 infection itself severely impairs both innate and adaptive immunity, characterized by reduced T cell counts and cytokine storm.

Purpose of the Study:

  • To identify factors influencing fungal coinfection in SARS-CoV-2 patients.
  • To analyze predisposing factors related to the fungus, host, and immune response alterations in CAPA development.
  • To elucidate the complex interplay leading to CAPA.

Main Methods:

  • This is a review article.
  • Literature search and synthesis of existing studies on CAPA.
  • Analysis of fungal, host, and viral (SARS-CoV-2) related factors.

Main Results:

  • Fungal factors include organism virulence and colonization ability.
  • Environmental factors in hospitals and patient comorbidities play a role.
  • SARS-CoV-2 induced immune dysfunction, including T cell reduction and cytokine storm, is a critical predisposing factor.

Conclusions:

  • Understanding the multifactorial nature of CAPA is crucial for clinical management.
  • Targeting fungal, host, and immune response factors may mitigate CAPA risk.
  • Further research is needed to develop effective prevention and treatment strategies for CAPA.
Keywords:
AspergillusCAPASARS-CoV-2coinfectioninteractionsusceptibility factors

More Related Videos

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.3K
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

28.1K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.3K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
426
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
445
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.6K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
302
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
359