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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery
Jinbao Wang1,2, Mingjian Li1,2, Langhuan Duan1,2
1School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Pharmaceutics
|November 11, 2022
Summary
Deep eutectic systems (DES) are novel vehicles for transdermal drug delivery. This review explores DES roles, mechanisms, and structure-activity relationships in transdermal drug delivery systems (TDDS).
Area of Science:
- Pharmacology
- Materials Science
- Drug Delivery
Background:
- Deep eutectic systems (DES) have emerged as promising carriers for transdermal drug delivery.
- They facilitate the delivery of diverse therapeutic agents, including polysaccharides, proteins, insulin, vaccines, nanoparticles, and herb extracts.
Purpose of the Study:
- To comprehensively review the application of DES in transdermal drug delivery systems (TDDS).
- To discuss the roles, modes of action, and structure-activity relationships of DES in TDDS.
- To provide a framework for developing novel DES-based TDDS.
Main Methods:
- Literature review of existing research on DES for transdermal delivery.
- Analysis of reported references and previous work.
- Discussion of skin permeation mechanisms for macromolecules and nanoparticles facilitated by DES.
Main Results:
- DES demonstrate significant potential in enhancing the transdermal permeation of various active compounds.
- The structure-activity relationship of DES is crucial for optimizing transdermal delivery efficacy.
- DES facilitate the skin penetration of challenging molecules like macromolecules and nanoparticles.
Conclusions:
- DES represent a versatile and effective platform for advanced transdermal drug delivery.
- Further research into DES properties can lead to the development of innovative transdermal systems.
- Understanding DES mechanisms is key to unlocking their full potential in drug delivery applications.
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