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Nanotherapeutics Plus Immunotherapy in Oncology: Who Brings What to the Table?
Elise Timon-David1, Carla Perez1, Anne Rodallec1
1COMPO-SMARTc CRCM, UMR Inserm 1068, CNRS UMR 7258, Aix Marseille Université U105, Institut Paoli Calmettes Inria Centre de Recherche Sophia Méditerranée, 13007 Marseille, France.
Abstract:
While the number of oncology-related nanotherapeutics and immunotherapies is constantly increasing, cancer patients still suffer from a lack of efficacy and treatment resistance. Among the investigated strategies, patient selection and combinations appear to be of great hope. This review will focus on combining nanotherapeutics and immunotherapies together, how they can dually optimize each other to face such limits, bringing us into a new field called nano-immunotherapy. While looking at current clinical trials, we will expose how passive immunotherapies, such as antibodies and ADCs, can boost nanoparticle tumor uptake and tumor cell internalization. Conversely, we will study how immunotherapies can benefit from nanotherapeutics which can optimize their lipophilicity, permeability, and distribution (e.g., greater tumor uptake, BBB crossing, etc.), tumor, tumor microenvironment, and immune system targeting properties.
Insights
Combining nanotherapeutics and immunotherapies, termed nano-immunotherapy, enhances cancer treatment efficacy. This approach optimizes drug delivery and immune response, overcoming treatment resistance in oncology.
Area of Science:
- Oncology
- Nanomedicine
- Immunotherapy
Background:
- Increasing cancer therapies face efficacy and resistance challenges.
- Patient selection and combination strategies offer potential solutions.
- Nano-immunotherapy emerges as a promising synergistic approach.
Purpose of the Study:
- To review the combination of nanotherapeutics and immunotherapies.
- To explore how these modalities can mutually enhance anti-cancer effects.
- To introduce the field of nano-immunotherapy.
Main Methods:
- Review of current clinical trials and literature.
- Analysis of passive immunotherapies (e.g., antibodies, ADCs) and nanoparticle interactions.
- Investigation of nanotherapeutics' role in optimizing immunotherapy properties.
Main Results:
- Passive immunotherapies can improve nanoparticle tumor accumulation and cellular uptake.
- Nanotherapeutics enhance immunotherapy properties like lipophilicity, permeability, and tumor targeting.
- Synergistic effects improve drug distribution, including potential blood-brain barrier crossing.
Conclusions:
- Nano-immunotherapy offers a dual optimization strategy for cancer treatment.
- This combination addresses limitations of current nanotherapeutics and immunotherapies.
- Further research into nano-immunotherapy holds significant promise for overcoming treatment resistance.
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