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Chitosan-Based Nanoparticles for Cardanol-Sustained Delivery System
Roberta Bussons Rodrigues Valério1, Nilvan Alves da Silva2, José Ribamar Paiva Junior2
1Programa de Pós-Graduação em Ciências Naturais, Universidade Estadual do Ceará, Fortaleza 60714-903, CE, Brazil.
Polymers
|November 11, 2022
Summary
Cardanol nanoparticles were created using natural polymers, enhancing its antioxidant power. This encapsulation improves cardanol
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Natural Product Chemistry
Background:
- Cardanol, derived from cashew nut shell liquid, possesses antioxidant and antibacterial properties.
- Enhancing cardanol's stability and efficacy through encapsulation is desirable for various applications.
- Polysaccharide-based nanoparticles offer biocompatible and biodegradable delivery systems.
Purpose of the Study:
- To isolate and purify cardanol from cashew nut shell liquid.
- To develop and characterize cardanol-loaded nanoparticles (NPs) using chitosan, sodium alginate, and Arabic gum.
- To evaluate the morphological, physicochemical, and antioxidant properties of the developed NPs.
Main Methods:
- Cardanol isolation and purification.
- Nanoparticle (NP) fabrication via polyelectrolyte complexation.
- Characterization using electron microscopy, infrared spectroscopy, and antioxidant activity assays.
Main Results:
- Spherical NPs with nanometric size (34-300 nm) and bimodal distribution were obtained.
- Infrared spectroscopy indicated physicochemical interactions and cross-linking between biopolymers.
- Cardanol-loaded NPs exhibited enhanced antioxidant potential compared to free cardanol.
Conclusions:
- Encapsulation of cardanol in polysaccharide NPs is an effective strategy to preserve its properties.
- The developed NPs offer improved protection, potential for targeted delivery, and minimized side effects.
- This approach holds promise for pharmaceutical, nutraceutical, and biomedical applications.
