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Related Concept Videos

Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

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Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
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Current Advances in Zika Vaccine Development.

Yuchen Wang1, Lin Ling1, Zilei Zhang1

  • 1Department of Inspection and Quarantine Technology Communication, Shanghai Customs College, Shanghai 201204, China.

Vaccines
|November 11, 2022
PubMed
Summary

Developing Zika virus (ZIKV) vaccines is crucial as mosquito control alone is insufficient. This review summarizes advancements in ZIKV vaccine development, highlighting various platforms evaluated for efficacy.

Keywords:
DNA vaccinesZika vaccinesZika viruslive attenuatedmRNA vaccinesvirus-like particleswhole inactivated

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Area of Science:

  • Virology
  • Immunology
  • Epidemiology

Background:

  • Zika virus (ZIKV), an arthropod-borne flavivirus, emerged globally causing significant health burdens.
  • Current ZIKV control relies on mosquito control, which has proven insufficient.
  • Understanding ZIKV pathogenesis and immune evasion is critical for effective interventions.

Purpose of the Study:

  • To provide a comprehensive summary of current advancements in Zika virus vaccine development.
  • To review various vaccine platforms evaluated for ZIKV prevention.

Main Methods:

  • Review of scientific literature on ZIKV vaccine research.
  • Analysis of different vaccine platforms including DNA, mRNA, viral vectors, VLPs, and others.
  • Evaluation of in vitro and in vivo study findings on vaccine-induced immune responses.

Main Results:

  • Multiple vaccine platforms (DNA, mRNA, viral vectors, VLPs, etc.) have been explored for ZIKV.
  • Vaccine candidates demonstrated ability to induce humoral and cellular immune responses.
  • Preclinical studies showed reduction in viremia and viral RNA titers with tested vaccines.

Conclusions:

  • No specific ZIKV vaccines or drugs are currently approved, but several are in clinical trials.
  • Diverse vaccine strategies show promise in preclinical and early clinical evaluations.
  • Continued research is essential to overcome ZIKV's public health threat.