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Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population
Huy Quang Quach1, Inna G Ovsyannikova1, Diane E Grill2
1Mayo Clinic Vaccine Research Group, Division of General of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20-44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.
Insights
A significant portion of vaccinated adults lack protective measles antibodies. This study highlights potential waning immunity, emphasizing the need for ongoing surveillance and potential booster strategies against measles outbreaks.
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- Measles control relies on high vaccine coverage and durable immunity.
- Assessing population immunity is crucial for outbreak prevention.
Purpose of the Study:
- To determine measles immunoglobulin G (IgG) seroprevalence in adults aged 20-44.
- To identify factors influencing measles-specific antibody levels.
Main Methods:
- A cohort of 1393 adults (20-44 years old) was studied.
- Enzyme-linked immunosorbent assay (ELISA) was used to measure measles-specific IgG antibodies.
Main Results:
- 37.6% of participants tested negative for measles IgG antibodies.
- Sex and age significantly influenced IgG levels in the cohort.
Conclusions:
- A substantial percentage of vaccinated adults exhibit suboptimal measles immunity.
- This subset may be vulnerable during future measles outbreaks, necessitating further investigation.
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