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A Review of Potential Therapeutic Strategies for COVID-19

Jiajia Meng1, Ruijiao Li1,2, Zhiqi Zhang1

  • 1Institute for Agro-Food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.

Viruses
|November 11, 2022
PubMed

Insights

This review examines therapeutic strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It identifies three key targets for developing effective treatments and preventing future outbreaks.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a heterogeneous global health threat with significant mortality.
  • SARS-CoV-2, an enveloped RNA virus, spreads primarily through respiratory droplets, posing a risk of resurgence upon relaxation of control measures.

Purpose of the Study:

  • To provide a systematic overview of potential therapeutic strategies for SARS-CoV-2 infection.
  • To identify key targets for the development of novel antiviral treatments and preventative measures.

Main Methods:

  • A systematic review of scientific literature published between 2019 and 2022.
  • Analysis of therapeutic strategies targeting virus entry, replication, and host immune response.

Main Results:

  • Identified virus entry, virus replication, and immune system modulation as primary targets for therapeutic intervention.
  • Highlighted the need for potent and specific antiviral compounds to combat SARS-CoV-2.

Conclusions:

  • Effective therapeutic options are urgently needed to manage the ongoing pandemic and prevent future outbreaks.
  • Targeting specific mechanisms of SARS-CoV-2 infection offers a promising avenue for drug development.
Keywords:
COVID-19SARS-CoV-2coronaviruspathogenesistherapeutic strategies

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