CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections
Noha Mousaad Elemam1,2, Iman Mamdouh Talaat1,2,3, Azzam A Maghazachi1,2
1Department of Clinical Sciences, College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah 27272, United Arab Emirates.
Abstract:
Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of chemokine expression helps shape the immune response and regulate viral clearance, improving clinical outcome. In particular, the chemokine ligand CXCL10 and its receptor CXCR3 were explored in a plethora of RNA and DNA viral infections. In this review, we highlight the expression profile and role of the CXCL10/CXCR3 axis in the host defense against a variety of RNA and DNA viral infections. We also discuss the interactions among viruses and host cells that trigger CXCL10 expression, as well as the signaling cascades induced in CXCR3 positive cells.
Related Concept Videos
Viruses with RNA Genomes
Size and Structure of Viral Genomes
Retrovirus Life Cycles
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Types of RNA
RNA Performs Diverse...


