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Cocktail, a Computer Program for Modelling Bacteriophage Infection Kinetics.

Anders S Nilsson1

  • 1Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, Sweden.

Viruses
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

Cocktail is a new computer program for modeling bacteriophage (phage) infection dynamics in chemostats. This tool aids in visualizing complex phage-bacteria interactions, crucial for advancing phage therapy applications.

Keywords:
bacteriophagecomputer programinfection kineticsmathematical modellingphage therapy

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Area of Science:

  • Microbiology
  • Computational Biology
  • Bioinformatics

Background:

  • Bacteriophage (phage) infections involve complex dynamics due to bacterial and phage multiplication and adaptation.
  • The growing interest in phage therapy necessitates accessible tools for understanding these interactions.
  • Visualizing phage-bacterial infection kinetics is challenging but essential for research and therapeutic development.

Purpose of the Study:

  • To introduce Cocktail, a user-friendly computer program for mathematical modeling of phage infection kinetics.
  • To provide a tool for visualizing complex phage-bacteria dynamics in a chemostat environment.
  • To support hypothesis generation for phage therapy applications.

Main Methods:

  • Cocktail utilizes coupled differential equations to model phage infection.
  • The program allows for detailed parameterization of both bacterial populations (16 parameters) and phage populations (8 parameters each).
  • Models incorporate factors like bacterial growth rates, phage resistance, inactive cells, biofilm formation, adsorption rates, and latency periods.

Main Results:

  • Cocktail provides a simplified method for visualizing complex phage-bacterial infection dynamics.
  • The program is designed for Windows 64-bit operating systems and features publicly available source code for user modification.
  • Models simulate *in vitro* phage infection kinetics, enabling hypothesis generation.

Conclusions:

  • Cocktail offers a valuable computational tool for researchers studying phage-bacteria interactions.
  • The program's flexibility and ease of use facilitate the exploration of phage infection dynamics.
  • Results generated by Cocktail can inform and guide the application of phage therapy.