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Do We Really Need Omicron Spike-Based Updated COVID-19 Vaccines? Evidence and Pipeline
Daniele Focosi1, Fabrizio Maggi2
1North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy.
Abstract:
The wild-type SARS-CoV-2 Spike-based vaccines authorized so far have reduced COVID-19 severity, but periodic boosts are required to counteract the decline in immunity. An accelerated rate of immune escape to vaccine-elicited immunity has been associated with Spike protein antigenic shifts, as seen in the Omicron variant of concern and its sublineages, demanding the development of Omicron Spike-based vaccines. Herein, we review the evidence in animal models and topline results from ongoing clinical trials with such updated vaccines, discussing the pros and cons for their deployment.
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