Related Experiment Video

Updated: Aug 22, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.2K

Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4

Baohai Rong1,2, Xiqi Chen2, Guangdong Xie2

  • 1The First Clinical Medicine School, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.

Combinatorial Chemistry & High Throughput Screening
|November 11, 2022
PubMed
Abstract

Insights

Circular RNAs (circRNAs) impact gastric cancer. This study found hsa_circ_0040039 (circSNTB2) down-regulation in gastric cancer, acting as a sponge for miR-6938-5p to regulate G0S2 and PDCD4, suggesting circSNTB2 as a diagnostic and therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally.
  • Circular RNAs (circRNAs) are increasingly recognized for their roles in cancer progression.
  • The specific functions of most circRNAs in gastric cancer remain largely unelucidated.

Purpose of the Study:

  • To investigate the mechanism of circRNA regulation in gastric cancer tumorigenesis.
  • To identify specific circRNAs involved in GC development.
  • To explore the potential of circRNAs as biomarkers for GC.

Main Methods:

  • Microarray analysis was employed to screen for differentially expressed circRNAs in gastric cancer.
  • hsa_circ_0040039 (circSNTB2) was identified as a down-regulated circRNA.
  • The interaction of circSNTB2 as a molecular sponge for miR-6938-5p was investigated.

Main Results:

  • circSNTB2 was found to be significantly down-regulated in gastric cancer tissues.
  • circSNTB2 acts as a sponge for miR-6938-5p, thereby up-regulating its expression.
  • G0/G1 switch gene 2 (G0S2) and programmed cell death gene 4 (PDCD4) were identified as target genes of miR-6938-5p, forming the circSNTB2/miR-6938-5p/G0S2 and PDCD4 pathways.

Conclusions:

  • circSNTB2 plays a crucial role in gastric cancer progression by modulating the miR-6938-5p/G0S2/PDCD4 axis.
  • circSNTB2 demonstrates potential as a novel biomarker for GC diagnosis.
  • circSNTB2 may serve as a target for future gastric cancer therapies.
Keywords:
G0S2Gastric cancerPDCD4biomarkercircSNTB2miR-6938-5p

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

5.6K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.7K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K