Related Experiment Video
Updated: Aug 22, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
595
Improved Adherence to ATA Medullary Thyroid Cancer Treatment Guidelines
Jessica Liu McMullin1, Jyotirmay Sharma1, Theresa Gillespie1
1Department of Surgery, Emory University, Atlanta, GA, USA.
Annals of Surgical Oncology
|November 11, 2022
Summary
Adherence to American Thyroid Association (ATA) guidelines for medullary thyroid cancer (MTC) improved after 2009. Following guidelines was associated with better overall survival for MTC patients.
Area of Science:
- Endocrinology
- Surgical Oncology
- Clinical Practice Guidelines
Background:
- The 2009 American Thyroid Association (ATA) guidelines aimed to standardize medullary thyroid cancer (MTC) care.
- Evaluating adherence and its impact on survival is crucial for refining MTC management.
Purpose of the Study:
- Assess national adherence to ATA MTC guidelines before and after 2009.
- Identify factors influencing adherence to MTC treatment guidelines.
- Determine if guideline-concordant treatment impacts MTC patient survival.
Main Methods:
- Analysis of 3421 MTC patients from the National Cancer Database (2009-2015).
- Evaluation of surgical extent adherence (R61-R66).
- Logistic regression and propensity score matching for adherence predictors and temporal comparison; Kaplan-Meier analysis for survival.
Main Results:
- Overall adherence to ATA MTC guidelines increased from 67% pre-2009 to 74% post-2009.
- Factors associated with non-adherence included female gender, older age, non-academic facilities, and proximity to treatment centers.
- Guideline adherence significantly correlated with improved overall survival (p < 0.01).
Conclusions:
- Medullary thyroid cancer treatment showed improved, though not universal, adherence to ATA guidelines post-2009.
- Non-adherence was more common in localized, non-invasive disease.
- Enhanced adherence to MTC guidelines presents an opportunity to improve patient outcomes and survival.
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