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Persistence of RNA Viruses in the Respiratory Tract: An Overview

Carlos Santiago-Olivares1, Eber Martínez-Alvarado1, Evelyn Rivera-Toledo1

  • 1Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.

Viral Immunology
|November 11, 2022
PubMed

Insights

Respiratory RNA viruses can persist after acute infections, potentially leading to chronic respiratory diseases. This review explores evidence for long-term RNA virus infections and their link to persistent respiratory symptoms.

Area of Science:

  • Virology
  • Immunology
  • Pulmonology

Background:

  • Respiratory RNA viruses cause significant acute lower respiratory tract infections and hospitalizations.
  • Viral clearance is not always complete, leading to potential persistence.
  • Chronic respiratory diseases are sometimes linked to persistent RNA virus infections, similar to DNA viruses.

Purpose of the Study:

  • To review evidence of RNA virus persistence in the respiratory tract.
  • To explore the relationship between long-term RNA virus infections and chronic respiratory symptoms.

Main Methods:

  • Literature review of studies on respiratory RNA virus persistence.
  • Examination of evidence from human and animal models.

Main Results:

  • Evidence suggests some respiratory RNA viruses can establish persistent infections.
  • Persistent infections may be linked to the development or exacerbation of chronic respiratory conditions.

Conclusions:

  • RNA virus persistence is a plausible mechanism contributing to chronic respiratory diseases.
  • Further research is needed to fully understand the role of persistent RNA viruses in respiratory health.
Keywords:
respiratory RNA virusesrespiratory tractviral persistence

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