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Trait anger representation in microstructural white matter tracts: A diffusion MRI study.

Zeinab Sinaeifar1, Mahsa Mayeli2, Mahdieh Shafie1

  • 1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Affective Disorders
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

This study used diffusion MRI connectometry to examine brain white matter tracts linked to anger. In males, specific tracts correlated with trait anger, but no significant brain pathways for anger were found in females.

Keywords:
ConnectometryDiffusion MRIState angerTrait anger

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Understanding brain microstructure is crucial for psychology and psychiatry.
  • White matter (WM) tracts underlying emotions, specifically anger, were investigated.
  • Potential sex differences in brain-emotion relationships were explored.

Purpose of the Study:

  • To investigate white matter (WM) tracts associated with anger using diffusion magnetic resonance imaging (DMRI) connectometry.
  • To explore potential sex differences in the relationship between brain structure and anger.
  • To identify specific brain circuits involved in anger expression and temperament.

Main Methods:

  • Diffusion magnetic resonance imaging (DMRI) connectometry was employed.
  • 225 healthy participants from the LEMON database were assessed using the State-Trait Anger Expression Inventory (STAXI).
  • Multiple regression models analyzed correlations between local connectomes and STAXI components, controlling for age and handedness.

Main Results:

  • No significant sex differences were found in state or trait anger levels.
  • In males, quantitative anisotropy (QA) in bilateral corticospinal tract (CST), splenium of corpus callosum (SCC), and other tracts negatively correlated with trait anger and trait anger temperament (TAT).
  • In females, QA in bilateral CST and SCC showed a positive correlation with trait anger and TAT, but this did not reach statistical significance.

Conclusions:

  • This is the first DMRI connectometry study to investigate WM circuits involved in anger.
  • Limbic system and movement-related pathways were linked to trait anger and anger expression in men.
  • No significant brain pathways related to anger were identified in women in this study.