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Real-World Treatment Patterns, Resource Use and Costs in Adult Patients With Atopic Dermatitis Receiving Systemic
Actas Dermo-Sifiliograficas
|November 11, 2022
Summary
Adults with moderate-to-severe atopic dermatitis (AD) face significant burdens, often requiring systemic treatments. This study highlights high comorbidity and costs, emphasizing the need for approved AD therapies.
Area of Science:
- Dermatology
- Real-world evidence
- Health economics
Background:
- Moderate-to-severe atopic dermatitis (AD) significantly impacts patient quality of life.
- Systemic treatments and phototherapy are often necessary for managing AD symptoms.
- Off-label drug use is common in treating AD.
Purpose of the Study:
- To describe sociodemographic and clinical characteristics of adults with AD initiating systemic treatment or phototherapy.
- To analyze treatment patterns, health resource utilization (HRU), and associated costs in a real-world setting.
- To evaluate the economic burden and treatment progression in adult AD patients.
Main Methods:
- Retrospective observational study using the BIG-PAC electronic medical records database.
- Inclusion criteria: adults diagnosed with AD initiating oral corticosteroids, immunosuppressants, biologics, or phototherapy (2012-2016).
- Follow-up period of 3 years post-treatment initiation; descriptive analysis of patient data, treatments, HRU, and costs.
Main Results:
- 1995 adult patients analyzed, mean age 60 years, 64% female; 84% initiated treatment at age 18+.
- High comorbidity rates: anxiety (38%), hypertension (36%), dyslipidemia (35%).
- Most patients (84%) started with oral corticosteroids; 50% required second-line and 12% third-line systemic therapy. Average 3-year cost was €3835 per patient.
Conclusions:
- Real-world data reveal a substantial comorbidity and economic burden in adult AD patients.
- Treatment patterns indicate a frequent need for multiple lines of systemic therapy.
- The findings underscore the necessity for systemic treatments specifically indicated for AD.
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