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The outcome of primary percutaneous coronary intervention in patients with stent thrombosis

Mukesh Kumar1, Ghulam Shabbir Shar1, Rajesh Kumar1

  • 1National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Indian Heart Journal
|November 11, 2022
PubMed

Insights

Primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) caused by in-stent thrombosis (ST) has high in-hospital mortality. Over 27% of patients undergoing primary PCI for ST-STEMI died during hospitalization.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Acute Coronary Syndromes

Background:

  • Primary percutaneous coronary intervention (PCI) is standard for ST-segment elevation myocardial infarction (STEMI).
  • The effectiveness of primary PCI for STEMI caused by in-stent thrombosis (ST) remains uncertain.
  • This study evaluates clinical characteristics and outcomes of primary PCI in ST-induced STEMI.

Purpose of the Study:

  • To assess the clinical features of patients with STEMI due to ST.
  • To determine the in-hospital outcomes of primary PCI in this patient group.
  • To clarify the efficacy of primary PCI for ST-induced STEMI.

Main Methods:

  • A cohort of 100 consecutive patients with STEMI due to ST were analyzed.
  • ST was defined by angiographic evidence of thrombus or occlusion at the previous stent site (TIMI flow 0-II).
  • Primary PCI was performed, and in-hospital mortality was observed.

Main Results:

  • The study included 69 male patients with a mean age of 58.9 years.
  • ST was acute in 40, sub-acute in 53, and late in 7 patients.
  • In-hospital mortality was 27% over a mean hospital stay of 4.93 days.

Conclusions:

  • In-hospital mortality following primary PCI for STEMI caused by ST is high.
  • Over one-quarter of patients undergoing primary PCI for ST-STEMI experienced in-hospital death.
  • Further research is needed to improve outcomes for ST-STEMI patients.
Abstract

Keywords:
MortalityPrimary percutaneous coronary interventionST-Segment elevation myocardial infarctionStent thrombosis

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