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Updated: Aug 22, 2025

Simple In-House Ultra-High Performance Capillary Column Manufacturing with the FlashPack Approach
Published on: December 4, 2021
Insights in column packing processes of narrow bore and capillary-scale columns: Methodologies, driving forces, and
Stan Perchepied1, Harald Ritchie2, Gert Desmet1
1Vrije Universiteit Brussel (VUB), Department of Chemical Engineering, Brussels, Belgium.
Abstract:
Having fundamental insights in the properties of stationary phases and in the driving forces during the column packing process, is crucial to obtain highly efficient and robust packed-bed column technologies for use in separation science. Here we discuss the properties of the most commonly-used stationary-phases, i.e., silica particulate materials, including fully-porous and core-shell silica particles and provide an overview of the most commonly used column hardware and available frit technologies. The different packing approaches that are considered are dry packing, high-pressure slurry packing, electrokinetic packing, and packing using centrifugal forces. In particular, sedimentation of particles in slurries and particle interaction during the packing process affecting the resulting sphere packing are discussed.
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