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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Gonadal and Placental Hormones01:24

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The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
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Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

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The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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The Ratio of X Chromosome to Autosomes02:45

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In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
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Sex-linked Disorders01:43

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Overview of the Reproductive System01:31

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The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
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Updated: Aug 22, 2025

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
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Consensus guide on prophylactic gonadectomy in different sex development.

Julio Guerrero-Fernández1, Pilar González-Peramato2, AmaiaRodríguez Rodríguez Estévez3

  • 1Grupo de Trabajo Sobre ADS/DSD de la Sociedad Española de Endocrinología Pediátrica (SEEP), Spain; Servicio de Endocrinología Pediátrica, Hospital Infantil La Paz, Madrid, Spain.

Endocrinologia, Diabetes Y Nutricion
|November 11, 2022
PubMed
Summary

Patients with disorders of sex development (DSD) carrying Y chromosome material face an increased risk of gonadal germ cell tumors (GCT). This guide evaluates current evidence to aid decisions on prophylactic gonadectomy.

Keywords:
Anomalías de la diferenciación sexualDesarrollo sexual diferenteDisorders of sex developmentGerm cell neoplasia in situGerm cell tumorGonadectomyGonadectomíaGonadoblastomaIntersexIntersexoNeoplasia in situ de células germinalesTumor de células germinales

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Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Patients with disorders of sex development (DSD), particularly those with Y chromosome material, have an elevated risk of gonadal germ cell tumors (GCT).
  • The risk assessment is complex due to variable factors, complicating decisions regarding prophylactic gonadectomy.
  • Existing clinical evidence is often limited, necessitating updated guidance.

Purpose of the Study:

  • To provide updated recommendations on prophylactic gonadectomy for patients with DSD.
  • To evaluate the current clinical evidence regarding GCT risk in DSD.
  • To aid clinicians in making informed decisions about gonadectomy in potential malignancy cases.

Main Methods:

  • Consensus-based review of the latest clinical evidence.
  • Evaluation of risk factors associated with GCT in DSD.
  • Synthesis of existing knowledge to inform updated guidelines.

Main Results:

  • The risk of GCT in DSD varies significantly based on multiple factors.
  • Clinical evidence supporting risk stratification and management is generally limited.
  • Updated knowledge highlights the complexity of gonadectomy decisions.

Conclusions:

  • Prophylactic gonadectomy decisions in DSD require careful consideration of individual risk factors.
  • Further research is needed to strengthen the evidence base for managing GCT risk in DSD.
  • This consensus guide aims to support informed clinical practice.