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Central nervous system adverse events of ceftazidime/avibactam: A retrospective study using Food and Drug

Xiaolong Guo1,2,3,4, Mingxing Guo1, Jiyang Li4

  • 1Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Journal of Clinical Pharmacy and Therapeutics
|November 12, 2022
PubMed
Abstract

Insights

Ceftazidime/avibactam (CAZ/AVI) antibiotics show increased nervous system adverse events compared to other drugs. Clinicians should monitor older patients and those on long treatments for potential neurological side effects.

Area of Science:

  • Pharmacovigilance
  • Infectious Diseases
  • Neurology

Background:

  • Antibiotics are frequently linked to central nervous system adverse events.
  • Ceftazidime/avibactam (CAZ/AVI) is a newer combination antibiotic.
  • Understanding the neurological safety profile of CAZ/AVI is crucial.

Purpose of the Study:

  • To analyze and compare nervous system adverse events associated with CAZ/AVI versus other antibiotics.
  • To identify specific neurological adverse events linked to CAZ/AVI.

Main Methods:

  • Utilized the FDA Adverse Event Reporting System (FAERS) database.
  • Analyzed reports from January 2015 to March 2022.
  • Employed the reporting odds ratios (RORs) method to detect safety signals.

Main Results:

  • Nervous system disorders accounted for up to 15.62% of CAZ/AVI adverse events.
  • A significant nervous system disorder signal was detected for CAZ/AVI compared to meropenem, ceftazidime, and ceftriaxone.
  • Encephalopathy and myoclonus showed significant RORs with CAZ/AVI.

Conclusions:

  • CAZ/AVI demonstrates a stronger signal for nervous system disorders in real-world data compared to meropenem, ceftazidime, and ceftriaxone.
  • These neurological events warrant clinical attention, particularly in elderly patients and those undergoing extended treatment courses.
Keywords:
FAERSceftazidime/avibactamcentral nervous systemsignal detection

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