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Kidney diseases.

Erica Daina1, Monica Cortinovis1, Giuseppe Remuzzi1

  • 1Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Immunological Reviews
|November 12, 2022
PubMed
Summary
This summary is machine-generated.

Dysregulation of the alternative pathway (AP) of complement contributes to kidney diseases. Complement-targeted therapies show promise but require personalized treatment strategies based on patient characteristics.

Keywords:
alternative pathway of complementcomplement inactivating agentscomplement systemglomerular diseasesrare kidney diseases

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Area of Science:

  • Nephrology
  • Immunology
  • Complement System Biology

Background:

  • The alternative pathway (AP) of complement is implicated in kidney injury, leading to hematuria, proteinuria, and chronic renal failure.
  • Genetic and acquired defects in complement regulatory proteins predispose individuals to AP-mediated kidney diseases.
  • Understanding these mechanisms is crucial for developing effective treatments.

Purpose of the Study:

  • To review the mechanisms underlying AP-mediated kidney diseases.
  • To discuss clinical evidence supporting complement-directed therapies.
  • To explore future perspectives in managing these conditions.

Main Methods:

  • Literature review of studies on complement system dysregulation in kidney diseases.
  • Analysis of clinical trial data for complement-targeted therapies.
  • Synthesis of current understanding of AP pathophysiology and therapeutic strategies.

Main Results:

  • Dysregulated AP activation is a key factor in various kidney pathologies.
  • Anti-complement therapies have significantly improved outcomes in atypical hemolytic uremic syndrome.
  • Innovative drugs targeting AP dysregulation offer new treatment avenues for kidney diseases.

Conclusions:

  • Complement-targeted therapies are effective but require individualized patient approaches.
  • Tailoring treatment based on clinical, histologic, genetic, and biochemical parameters is essential.
  • Further research and collaboration are vital for advancing patient care in AP-mediated kidney diseases.