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Updated: Aug 22, 2025

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Published on: June 2, 2014
Migraine and Gastroparesis.
Karissa N Arca1, Jacqueline Cai2, Fangfang Wang2
1Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ, USA. arca.karissa@mayo.edu.
Migraine and gastroparesis share overlapping pathophysiology and clinical features. Recognizing this connection is crucial for optimizing treatment strategies for patients experiencing both conditions.
Area of Science:
- Neurogastroenterology
- Neurology
- Gastroenterology
Background:
- Migraine is a prevalent, disabling neurological disorder.
- Gastroparesis is a gastrointestinal dysmotility disorder characterized by delayed gastric emptying.
- An increasing body of evidence suggests a significant overlap between migraine and gastroparesis.
Purpose of the Study:
- To review recent literature on the shared pathophysiology and clinical manifestations of migraine and gastroparesis.
- To highlight management considerations for patients with coexisting migraine and gastroparesis.
Main Methods:
- Literature review of recent studies on migraine and gastroparesis.
- Analysis of the interplay between central, autonomic, and enteric nervous systems.
- Examination of clinical presentations and treatment implications.
Main Results:
- Gastroparesis can occur during and between migraine attacks, affecting oral medication absorption.
- Autonomic nervous system dysfunction is a key feature in both conditions.
- Noninvasive vagus nerve stimulation shows promise for both migraine and gastroparesis.
Conclusions:
- The bidirectional gut-brain axis connection is critical in understanding migraine and gastroparesis.
- Management strategies must account for concurrent gastroparesis in migraine patients.
- Vagus nerve modulation represents a potential therapeutic target for both disorders.
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