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Studies on stabilization of collagen using Cr-doped polydopamine complex.
P David Dayanidhi1, P Anithabanu1, V G Vaidyanathan1
1Advanced Materials Laboratory, CSIR-Central Leather Research Institute, Sardar Patel Road, Adyar, Chennai 600020, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Biophysical Chemistry
|November 12, 2022
Summary
Chromium-doped polydopamine (Cr-PDA) stabilizes collagen, enhancing its properties for biomaterial development. This eco-friendly approach offers an alternative to traditional tanning methods.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Biochemistry
Background:
- Collagen stabilization is crucial for biomaterial development.
- Polydopamine (PDA) and chromium are known collagen binders.
- Chromium use in leather tanning is restricted due to environmental concerns.
Purpose of the Study:
- To investigate chromium-doped polydopamine (Cr-PDA) as a collagen stabilizing agent.
- To evaluate Cr-PDA's potential as an eco-friendly alternative to chromium tanning.
Main Methods:
- Preparation and characterization of Cr-PDA using FE-SEM, DLS, and FT-IR.
- Assessment of collagen's triple helical structure using CD spectroscopy.
- Evaluation of collagen fibrillation, stability, viscosity, hydrophobicity, and tensile strength after Cr-PDA treatment.
Main Results:
- Cr-PDA did not alter collagen's triple helical structure.
- Cr-PDA delayed collagen fibrillation and increased its tensile strength.
- Cr-PDA enhanced collagen stability and hydrophobicity, though less than PDA alone.
- Cr-PDA reduced collagen viscosity.
Conclusions:
- Cr-PDA effectively stabilizes collagen, improving its physical properties.
- Cr-PDA shows potential as an eco-friendly crosslinking agent for collagen-based biomaterials.
- This approach may offer a sustainable alternative to conventional chromium tanning.
