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Updated: Aug 22, 2025
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Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
Published on: July 1, 2018
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How Streptococcus suis escapes antibiotic treatments.
Cristina Uruén1, Carla García1, Lorenzo Fraile2
1Unit of Microbiology and Immunology, Faculty of Veterinary, University of Zaragoza, 50017, Zaragoza, Spain.
Veterinary Research
|November 12, 2022
Summary
Streptococcus suis causes severe infections in pigs and humans, leading to widespread antibiotic resistance. Understanding resistance mechanisms is crucial for developing new treatments and alternative strategies like phage therapy.
Area of Science:
- Veterinary Microbiology
- Antimicrobial Resistance
- Zoonotic Diseases
Background:
- Streptococcus suis is a significant zoonotic pathogen causing sepsis and meningitis in pigs and humans.
- Economic losses in swine production are substantial due to S. suis infections.
- Extensive antibiotic use has led to high rates of resistance in S. suis.
Purpose of the Study:
- To investigate the mechanisms of antibiotic resistance and tolerance in Streptococcus suis.
- To highlight the urgent need for alternative strategies to combat S. suis infections.
Main Methods:
- Genomic analysis of S. suis to identify resistance genes and mobile genetic elements.
- Investigation of microcolony formation and its role in antibiotic tolerance.
- Review of current resistance patterns and genetic origins.
Main Results:
- High rates of resistance to tetracyclines, lincosamides, and macrolides are globally prevalent.
- Multiple genetic mechanisms contribute to S. suis resistance, including enzyme production and target mutations.
- Horizontal gene transfer and microcolony formation facilitate rapid acquisition of multiresistance.
Conclusions:
- Streptococcus suis exhibits complex resistance and tolerance mechanisms, driven by genetic factors and microbial interactions.
- Novel antimicrobial strategies and alternative therapies such as phage therapy and vaccination are essential.
- Further research into resistance mechanisms can guide the development of effective treatments against S. suis.
Keywords:
Streptococcus suisantibiotic resistanceantibiotic tolerancemultidrug resistancerecalcitranceMore Related Videos
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