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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
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Combating coxsackievirus B infections.
Abdulaziz Alhazmi1,2, Magloire Pandoua Nekoua1, Ambroise Mercier1
1Laboratoire de Virologie ULR3610, Université de Lille et CHU de Lille, Lille, France.
Reviews in Medical Virology
|November 13, 2022
Summary
Coxsackieviruses B (CVB) are RNA viruses causing diverse diseases. Current research explores antiviral drugs, vaccines, and alternative therapies to combat CVB infections and related pathologies.
Area of Science:
- Virology
- Infectious Diseases
- Immunology
Background:
- Coxsackieviruses B (CVB) are enteroviruses causing a spectrum of human illnesses, from mild to severe conditions like cardiomyopathy and type 1 diabetes.
- Effective control strategies against CVB infections remain a significant challenge in public health.
Purpose of the Study:
- To review current and emerging strategies for controlling Coxsackieviruses B (CVB) infections.
- To highlight the potential of various therapeutic and prophylactic interventions against CVB-induced diseases.
Main Methods:
- Review of existing literature on antiviral drugs targeting viral or host factors.
- Examination of vaccine development for CVB prevention.
- Analysis of alternative therapeutic approaches including repurposed drugs, miRNA targeting, plant extracts, and probiotics.
Main Results:
- Antiviral drugs and vaccines have demonstrated potential in preclinical studies (in vitro and animal models).
- Repurposed drugs, miRNA-based strategies, plant extracts, and probiotics show promise in combating CVB.
- Ongoing clinical trials for vaccines and drugs offer hope for future treatments.
Conclusions:
- A multifaceted approach involving direct antivirals, vaccines, and novel strategies is crucial for managing CVB.
- Continued research and clinical evaluation are essential to translate promising findings into effective clinical practice for CVB-related diseases.
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