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Updated: Aug 22, 2025

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Predictors of Social-Emotional Development and Adaptive Functioning in School-Age Children with Intestinal Failure

Bianca C Bondi1,2,3, Anna Gold4,5,6,7, Christina Belza1

  • 1Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, Canada.

Journal of Clinical Psychology in Medical Settings
|November 13, 2022
PubMed

Insights

Children with intestinal failure (IF) show social-emotional and adaptive functioning challenges. Early identification of medical and demographic risks can guide interventions for better outcomes.

Area of Science:

  • Pediatric gastroenterology
  • Developmental psychology
  • Neuroscience

Background:

  • Previous research on pediatric intestinal failure (IF) primarily focused on neurocognition.
  • There is a need to understand the broader psychosocial and functional outcomes in children with IF.

Purpose of the Study:

  • To investigate social-emotional and adaptive functioning in children with IF.
  • To identify medical and demographic factors associated with these functioning domains.

Main Methods:

  • Neuropsychological assessments were conducted on 63 children in an IF rehabilitation program.
  • Caregiver and teacher questionnaires were used, with results compared to normative data.
  • Exploratory analyses examined medical and demographic predictors of functioning.

Main Results:

  • Children with IF exhibited poorer executive, internalizing, behavioral, and adaptive functioning compared to norms.
  • Teachers reported more executive dysfunction than caregivers.
  • Specific factors like necrotizing enterocolitis, immigrant status, and living situation were linked to certain functional outcomes.

Conclusions:

  • Children with IF experience significant social-emotional and adaptive functioning concerns.
  • Identifying at-risk individuals through medical and demographic screening is crucial for timely intervention.
Abstract

Keywords:
Adaptive functioningIntestinal failureNeuropsychologyPediatricsSocial-emotional

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