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Updated: Aug 22, 2025
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A systematic review on the use of explainability in deep learning systems for computer aided diagnosis in radiology:
Arjan M Groen1, Rik Kraan1, Shahira F Amirkhan1
1Department of Radiology and Nuclear Medicine, Amsterdam Movement Sciences, Amsterdam UMC Location AMC, Amsterdam, Netherlands.
Objectives:
This study aims to contribute to an understanding of the explainability of computer aided diagnosis studies in radiology that use end-to-end deep learning by providing a quantitative overview of methodological choices and by discussing the implications of these choices for their explainability.
Methods:
A systematic review was executed using the preferred reporting items for systemic reviews and meta-analysis guidelines. Primary diagnostic test accuracy studies using end-to-end deep learning for radiology were identified from the period January 1st, 2016, to January 20th, 2021. Results were synthesized by identifying the explanation goals, measures, and explainable AI techniques.
Results:
This study identified 490 primary diagnostic test accuracy studies using end-to-end deep learning for radiology, of which 179 (37%) used explainable AI. In 147 out of 179 (82%) of studies, explainable AI was used for the goal of model visualization and inspection. Class activation mapping is the most common technique, being used in 117 out of 179 studies (65%). Only 1 study used measures to evaluate the outcome of their explainable AI.
Conclusions:
A considerable portion of computer aided diagnosis studies provide a form of explainability of their deep learning models for the purpose of model visualization and inspection. The techniques commonly chosen by these studies (class activation mapping, feature activation mapping and t-distributed stochastic neighbor embedding) have potential limitations. Because researchers generally do not measure the quality of their explanations, we are agnostic about how effective these explanations are at addressing the black box issues of deep learning in radiology.
